By H. Arnouk
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Additional resources for Advancements in Tumor Immunotherapy, Cancer Vaccines
The study was not powered to detect survival difference between the two treatment arms, however there was a protocol-specified requirement to follow each patient for survival up to 36 months. This analysis demonstrated that patients treated with sipuleucel-T had significant improvement in overall survival. 01). The second phase III study revealed no statistically significant benefit in TTP in the overall group (ADIS R&D profile, 2006). , 2009). A total of 225 patients were randomised in both studies to sipuleucel-T (n=147) or placebo (n=78).
Another study used a vaccine that contained electrofused allogeneic dendritic cells and autologous tumor-derived cells in patients with metastatic renal cell carcinoma. The tumors were processed into a single-cell suspension and cryopreserved. Dendritic Cells were generated from peripheral blood mononuclear cells isolated from volunteers and cultured with granulocyte macrophage colony-stimulating factor, interleukin 4, and tumor necrosis factor-alpha. Dendritic cells were then fused to the patient-derived renal cell carcinoma with serial electrical pulses.
This chapter reviews the development of vaccine cancer immunotherapy in genitourinary cancers. S. fast track for approval Prostate Sipuleucel-T Dendritic Cells Approved in 2010 Prostate PROSTVAC Prostate-specific antigen Seeking FDA approval Bladder OncoTice Bacille Calmette-Guerin Approved Table 1. Approved Genitourinary Cancer Vaccines 22 Advancements in Tumor Immunotherapy and Cancer Vaccines 2. , 2009). Prostatectomy and radiation therapy has been successful in approximately 80% of patients who are diagnosed to be in the early stages of prostate cancer.