Download Advances in Nanotheranostics I: Design and Fabrication of by Zhifei Dai PDF

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By Zhifei Dai

This publication highlights the new advances in nanotheranostics from easy study to capability purposes, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. each one bankruptcy demonstrates multifunctional nanoparticles with themes masking focusing on, imaging, supply, diagnostics, and remedy as new modalities for melanoma theranostics. This finished e-book provides specialist perspectives at the newest advancements in theranostic nanomedicine.

It specializes in power theranostic functions of multifunctional nanoparticles starting from picking out noninvasively melanoma cells through molecular detection, and visualizing in vivo drug supply through distinction superior imaging, to destroying melanoma telephone s with minimum negative effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally offers an interdisciplinary survey of nanotheranostics and as such is a precious source for researchers and scholars in comparable fields.

Zhifei Dai is a Professor on the division of Biomedical Engineering, university of Engineering, Peking collage, China.

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Liang HP, Wan LJ, Bai CL, Jiang L (2005) Gold hollow nanospheres: tunable surface plasmon resonance controlled by interior-cavity sizes. J Phys Chem B 109:7795–7800 8. Xu XD, Cortie MB (2006) Shape change and color gamut in gold nanorods, dumbbells, and dog bones. Adv Funct Mater 16:2170–2176 9. Lu XM, Au L, McLellan J, Li ZY, Marquez M, Xia YN (2007) Fabrication of cubic nanocages and nanoframes by dealloying au/ag alloy nanoboxes with an aqueous etchant based on Fe(NO3)3 or NH4OH. Nano Lett 7:1764–1769 10.

NP3-mediated thermo-chemotherapy demonstrated greater antitumor activity than free DOX, NP3, or liposomal DOX, which represents a promising approach to effective anticancer therapy. DOX-loaded 28 L. Wang et al. HAuNSs can be further conjugated with a cyclic peptide targeting EphB4, a member of the Eph family of receptor tyrosine kinases that are overexpressed on the cell membrane of multiple tumors and angiogenic blood vessels. Li et al. also observed an increased uptake of targeted nanoparticles (T-DOX@ HAuNSs) in three EphB4-positive tumors both in vitro and in vivo [155].

The right indicates number of modulated proteins by AuNRs and the representative protein quantitative confirmation using western blot analyses. (e) The effects of AuNRs on the migration and invasion abilities of cancer cells, using transwell migration and invasion assays. (f) Effects of AuNRs on the intracellular ATP level, using a luciferase-based luminescence assay that is normalized to protein concentrations. Before ATP measurement, the cells are pretreated with or without 100 mM 2-deoxyglucose (2-DG), 1 μM oligomycin (OM), or 50 μ M AuNRs for 24 h.

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