Download Animal Pain: Perception and Alleviation by Lawrence Kruger, Barbara E. Rodin (auth.), Ralph L. PDF

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By Lawrence Kruger, Barbara E. Rodin (auth.), Ralph L. Kitchell, Howard H. Erickson (eds.)

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Rec. 198: 643-656, 1980. 24. , and H. A. McRitchie. Neonatal capsaicin and thermal nociception: a paradox. Brain Res. 215: 414-418, 1981. 25. Chapman, L. , A. 0. Ramos, H. Goodell, and H. G. Wolff. Neurohumoral features 26. 27. 28. 29. 30. 31. of afferent fibers in man. Their role in vasodilatation, inflammation, and pain. Arch. Neural. 4: 49-82, 1961. Coggeshall, R. , M. L. Applebaum, M. Fazen, T. B. Stubbs, and M. T. Sykes. Unmyelinated axons in human ventral roots, a possible explanation for the failure of dorsal rhizotomy to relieve pain.

Neurophysiological studies suggest that an endogenous analgesic system exists, which at least partly operates on dorsal horn neurons via tryptaminergic pathways. The endogenous opioids have been implicated at brain stem and/or spinal levels. Morphine, the morphine antagonist naloxone, and endogenous opioids all contribute to the elucidation of the mechanisms involved. In addition to these chemicals there is good evidence that descending inhibition can be mediated via axons containing serotonin that have cell bodies in the nucleus raphe magnus of the brain stem (19).

One important aspect of this work is the opportunity it provides, through pharmacological study of the neurons and their synaptic connections, to establish highly specific methods for interfering therapeutically with activity in the 30 lggo nociceptive pathways. This prize, I am sure, motivates a good deal of current research. Classification of dorsal horn neurons The gray matter of the spinal cord appears stratified or laminated in cross sections, with both the neuronal somata and their dendrites and the axons contributing to the pattern.

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